Photothermal Sensitive Nanocomposite Hydrogel for Infectious Bone Defects

Infectious bone defects, a significant challenge in clinical settings, often need advanced therapeutic interventions. This study introduces a novel treatment system combining a photothermal therapy hydrogel with a pulsed drug release mechanism. The system employs a hydrogel matrix that is sensitive to the thermal fluctuations characteristic of bone defect sites, enables controlled and localized drug release. The key component of this system is the integration of mild photothermal agents, which are activated within 40-43°C to improve the precision and effectiveness of drug delivery. Our results indicate that the photothermal response significantly improves the localized delivery of therapeutic agents, reducing systemic side effects and enhancing efficacy at the defect site. The pulsed release with mild PTT addresses both infection control and bone regeneration. This innovative approach marks a substantial improvement in bone defect treatments, offering a more targeted, effective, and patient-friendly alternative to conventional methods. Our research aims to expand its applicability to a broader range of tissue regeneration scenarios, underscoring its potential in the field of regenerative medicine.