Development of pyrurate dehydrogenase complex

The structure and functional properties of pyruvate dehydrogenase complex (PDHC) have been reviewed briefly.PDHC is a mitochondrial multienzyme complex including pyruvate dehydrogenase(E_1),dihydrolipoamide acetyltransferase(E_2),dihydrolipoamide dehydrogenase(E_3),pyruvate dehydrogenase,pyruvate dehydrogenase phosphatase,five cofactor and protein X.Pyruvate dehydrogenase complex converts pyruvate to aceryl-CoA that is subatrate for the citric acid cycle.Lactic acidosis can arise from the deficiency of PDHC.