神经营养因子
神经保护
癫痫
纽恩
神经发生
脑源性神经营养因子
红藻氨酸
医学
双皮质醇
海马体
内科学
内分泌学
神经科学
心理学
齿状回
免疫组织化学
受体
谷氨酸受体
作者
Satoshi Kuramoto,Takao Yasuhara,Takashi Agari,Akihiko Kondo,Jing Meng,Yoichiro Kikuchi,Aiko Shinko,Takaaki Wakamori,Masahiro Kameda,Feifei Wang,Kyohei Kin,Satoru Edahiro,Yasuyuki Miyoshi,Isao Date
出处
期刊:Brain Research
[Elsevier]
日期:2011-01-01
卷期号:1368: 281-289
被引量:27
标识
DOI:10.1016/j.brainres.2010.10.054
摘要
Brain-derived neurotrophic factor (BDNF) is a well neurotrophic factor with neuroprotective potentials for various diseases in the central nervous system. However several previous studies demonstrated that BDNF might deteriorate symptoms for epilepsy model of animals by progression of abnormal neurogenesis. We hypothesized that continuous administration of BDNF at low dose might be more effective for epilepsy model of animals because high dose of BDNF was used in many studies. BDNF-secreting cells were genetically made and encapsulated for transplantation. Rats receiving BDNF capsule showed significant amelioration of seizure stage and reduction of the number of abnormal spikes at 7 days after kainic acid administration, compared to those of control group. The number of BrdU and BrdU/doublecortin positive cells in the hippocampus of BDNF group significantly increased, compared to that of control group. NeuN positive cells in the CA1 and CA3 of BDNF group were significantly preserved, compared to control group. In conclusion, low dose administration using encapsulated BDNF-secreting cells exerted neuroprotective effects with enhanced neurogenesis on epilepsy model of rats. These results might suggest the importance of the dose and administrative way of this neurotrophic factor to the epilepsy model of animals.
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