生物转化
代谢物
细菌
肠道细菌
肠道菌群
化学
代谢途径
2型糖尿病
生物化学
生物
新陈代谢
酶
糖尿病
内分泌学
遗传学
作者
Guisheng Zhou,Ying Peng,Lijuan Zhao,Mengyue Wang,Xiaobo Li
标识
DOI:10.1021/acs.jafc.6b04498
摘要
Siraitia fructus, known as Luo-Han-Guo (LHG) in Chinese, shows good antidiabetic activity. Gut microbiota have emerged as parameter of the pathophysiology of type 2 diabetes (t2D) mellitus. In this study, in vitro biotransformation of LHG extract by t2D and normal human intestinal microbiota was analyzed using ultraperformance liquid chromatography with time-of-flight mass spectrometry. A total of 19 and 12 metabolites were characterized in t2D and normal human intestinal microbiota, respectively. These metabolites were formed by a series of metabolic reactions including deglycosylation, oxidation, isomerization, and/or deoxidation. The metabolite classes of LHG extract in normal and t2D human intestinal microbiota were nearly the same, but oxidation and isomerization reactions were usually present in t2D human intestinal bacteria. This might be due to metabolic activation by pathological human intestinal bacteria. Our study indicates that there are differences in the biotransformation of LHG extract in normal and t2D human intestinal bacteria.
科研通智能强力驱动
Strongly Powered by AbleSci AI