Objective To explore the prevention and treatment of pancreatic fistula secondary to pancreaticoduodenectomy.Methods We retrospectively analyzed the clinical data of 14 pancreatic fistula cases after pancreaticoduodenectomy from January 2008 and November 2010.Results There were 14 patients with pancreatic fistula after pancreaticoduodenectomy,and the incidence rate was 18.4 %.And 12 patients were cured by expectant treatment.The other 2 patients underwent re-operation.There was one patient dead,and the death rate was 7.1%.Conclusions The incidence and death rate of pancreatic fistula after pancreaticoduodenectomy are still high.The reduce the rate of pancreatic fistula lies in the reasonable treatment during or after operation.