Expressions and significances of Fas/FasL and Bcl-2 in placentae of cases with preeclampsia

Objective:To explore the changes of expressions of Fas antigen(Fas) and its ligand(FasL),Bcl-2 in syncytiotrophoblast of placentae of pregnant women with preeclampsia and their significances. Methods:Immunohistochemical SP method was used to detect the expression levels of Fas,FasL and Bcl-2 in placental tissues of 20 normal late pregnant women(normal late pregnancy group),20 pregnant women with mild preeclampsia(mild preeclampsia group) and 20 pregnant women with severe preeclampsia(severe preeclampsia group). Results:Fas,FasL and Bcl-2 mainly expressed in cytoplasm and cell membrane of placental syncytiotrophoblast.The expression levels of FasL and Bcl-2 in mild preeclampsia group and severe preeclampsia group were(62.28±4.92),(80.67±6.19) and(41.74±6.38),(64.42±5.43),respectively,which were significantly lower than those in normal late pregnancy group((80.72±6.01),(92.49±7.88))(P0.01).The expression levels of Fas in mild preeclampsia group and severe preeclampsia group were(55.94±4.35) and(75.98±6.01),respectively,which were significantly higher than that in normal late pregnancy group(40.58±5.43)(P0.01). Conclusion:The unbalance of Fas,FasL and Bcl-2 expressions in placental syncytiotrophoblast of pregnant women with preeclampsia may be related to the occurrence and development of preeclampsia.