In Vitro Study on the Antibacterial Activities of a Medicinal Intermediate,Solanesol

OBJECTIVE Solanesol,purified from abandoned tobacco leaf,is an important medicinal intermediate.Our aim of this study was to observe the antibacterial effect of solanesol against the gram-negative and gram-positive bacteria.METHODS Two classic methods,broth dilution and two-fold dilution,were employed to examine the activities of solanesol on several standard strains and those collected from clinical patients.RESULTS and CONCLUTION Solanesol demonstrated significant antibacterial activities against all of the gram-negative(Escherichia coli and Pseudomonas aeruginosa)and most of the gram-positive bacteria(Staphylococcus aureus and Mycobacterium phlei)tested.Low antibacterial effects were shown for the two strains,Bacillus subtilis and Bacillus circulans.