Determination of seven azole antifungal drugs in human serum by UHPLC-DAD and its clinical application

Conclusion: We developed and validated a simple, sensitive and selective UHPLC-DAD method for the simultaneous determination in human serum of seven azole antifungal drugs. The method is successfully applied to patient biological samples and is suitable for clinical applications, such as therapeutic drug monitoring. Since this method has been implemented, confrontation of laboratory results and clinical data has demonstrated the interest of