阳离子聚合
小泡
肺表面活性物质
化学
烷基
抗菌剂
细胞毒性
链条(单位)
铵
两亲性
有机化学
组合化学
膜
生物化学
聚合物
共聚物
体外
物理
天文
作者
Aurora Pinazo,V. Petrizelli,M. Bustelo,Ramon Pons,María Pilar Vinardell,Montserrat Mitjans,Angeles Manresa,Lourdes Pérez
标识
DOI:10.1016/j.colsurfb.2016.01.020
摘要
Cationic double chain surfactants have attracted much interest because they can give rise to cationic vesicles that can be used in biomedical applications. Using a simple and economical synthetic approach, we have synthesized four double-chain surfactants with different alkyl chain lengths (LANHCx). The critical aggregation concentration of the double chain surfactants is at least one order of magnitude lower than the CMC of their corresponding single-chain LAM and the solutions prepared with the LANHCx contain stable cationic vesicles. Encouragingly, these new arginine derivatives show very low haemolytic activity and weaker cytotoxic effects than conventional dialkyl dimethyl ammonium surfactants. In addition, the surfactant with the shortest alkyl chain exhibits good antimicrobial activity against Gram-positive bacteria. The results show that a rational design applied to cationic double chain surfactants might serve as a promising strategy for the development of safe cationic vesicular systems.
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