Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy

(Cell Stem Cell 29, 1298–1314.e1–e10; September 1, 2022)Figure S1Characterization of Drp1WT and Drp1ΔPax7ER satellite cells (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) (Cell Stem Cell 29, 1298–1314.e1–e10; September 1, 2022) Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagyHong et al.Cell Stem CellAugust 22, 2022In BriefHong et al. illustrate that mitochondrial dynamics are required for tissue regeneration. Mitochondrial fission facilitates stem cell function via OXPHOS and mitophagy regulation. The genetic (or aging-related) loss of the mitochondrial fission regulator DRP1 in muscle stem cells blunts their proliferation and regenerative capacity, whereas DRP1 re-establishment rescues these defects. Full-Text PDF Open Access