Strategies for the delivery of RNA therapeutics to diseased heart tissue

Local delivery systems are crucial to improve RNA retention and diffusion through the extracellular matrix (ECM), while cell-type - specific strategies targeting cardiomyocytes and fibroblasts can enhance precision within a heterogeneous cardiac microenvironment (CME). These approaches represent a fundamental basis for the rational design of RNA therapeutics to overcome biological barriers and enable efficient, targeted delivery to cardiac tissue.