Liposomal Bupivacaine’s Plausibility Fails to Translate

Editorial| May 2024 Liposomal Bupivacaine's Plausibility Fails to Translate This article has an Audio Podcast Michael R. Fettiplace, M.D., Ph.D. Michael R. Fettiplace, M.D., Ph.D. 1Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois. https://orcid.org/0000-0001-6946-8355 Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information This editorial accompanies the article on p. 906. Accepted for publication January 29, 2024. Address correspondence to Dr. Fettiplace: Anesthesiology May 2024, Vol. 140, 868–870. https://doi.org/10.1097/ALN.0000000000004934 Connected Content Article: Analgesic Effectiveness of Liposomal Bupivacaine versus Plain Local Anesthetics for Abdominal Fascial Plane Blocks: A Systematic Review and Meta-analysis of Randomized Trials Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Search Site Citation Michael R. Fettiplace; Liposomal Bupivacaine's Plausibility Fails to Translate. Anesthesiology 2024; 140:868–870 doi: https://doi.org/10.1097/ALN.0000000000004934 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll PublicationsAnesthesiology Search Advanced Search Topics: liposomes For over a century, anesthesiologists have sought to extend the utility, duration, and safety of local anesthetics, from the original topical instillation of cocaine onto the eye1 to more targeted injections of long-acting local anesthetics upon nerve bundles. This progression included the modification of cocaine to produce nonaddictive local anesthetics (e.g., procaine) and the addition of an amide linkage that avoids degradation by esterase. Certain innovations, like neuraxial catheters, produced dramatic results and improved the pain experience for millions of parturients. Other biologically plausible interventions failed to produce clinical benefits compared to the existing standard of care, with examples including etidocaine and interpleural catheters.2 In this issue of Anesthesiology, Hussain et al.3 address two biologically plausible interventions intended to extend the effectiveness of local anesthetics: liposomal bupivacaine and truncal fascial plane blocks. Liposomal bupivacaine was originally described as early as 1986 as a... You do not currently have access to this content.