生物
细菌
微生物代谢
肠道菌群
消化(炼金术)
新陈代谢
营养物
免疫系统
采样(信号处理)
微生物学
生态学
生物化学
免疫学
遗传学
滤波器(信号处理)
色谱法
化学
计算机科学
计算机视觉
作者
Simon Yersin,Pascale Vonaesch
标识
DOI:10.1016/j.tim.2024.02.013
摘要
Abstract
The small intestinal microbiota (SIM) is essential for gastrointestinal health, influencing digestion, immune modulation, and nutrient metabolism. Unlike the colonic microbiota, the SIM has been poorly characterized due to sampling challenges and ethical considerations. Current evidence suggests that the SIM consists of five core genera and additional segment-specific taxa. These bacteria closely interact with the human host, regulating nutrient absorption and metabolism. Recent work suggests the presence of two forms of small intestinal bacterial overgrowth, one dominated by oral bacteria (SIOBO) and a second dominated by coliform bacteria. Less invasive sampling techniques, omics approaches, and mechanistic studies will allow a more comprehensive understanding of the SIM, paving the way for interventions engineering the SIM towards better health.
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