Biomimetic Barium Titanate/PLA Scaffold with Shape Memory and Bioelectro-Active Capacities Promotes Bone Regeneration

The BT/PLA scaffold, combining shape-memory and piezoelectric effects, shows significant bone regeneration potential. Its degradability with 4D printing may facilitate translation of personalized bone repair implants from bench to bedside. Transcriptome sequencing suggests its osteogenic effect may involve the PI3K-Akt pathway, providing a basis for optimizing molecular targets in future bone regenerative materials and reinforcing the study's scientific value in material design and mechanistic exploration.