免疫学
嗜碱性粒细胞
背景(考古学)
抗体
炎症
免疫球蛋白E
获得性免疫系统
生物
免疫系统
过敏
过敏性炎症
先天免疫系统
免疫
古生物学
作者
Kang Chen,Yujing Hao,Mauricio Guzmán,Genxia Li,Andrea Cerutti
标识
DOI:10.1016/j.it.2023.04.003
摘要
An increasing number of human diseases, including allergies, infections, inflammation, and cancer, involve roles for basophils. Traditionally viewed as the rarest leukocytes that are present only in the circulation, basophils have recently emerged as important players in systemic as well as tissue-specific immune responses. Their functions are regulated by immunoglobulins (Igs), and this enables basophils to integrate diverse adaptive and innate immunity signals. IgE is well known to regulate basophil responses in the context of type 2 immunity and allergic inflammation; however, growing evidence shows that IgG, IgA, and IgD also shape specific aspects of basophil functions relevant to many human diseases. We discuss recent mechanistic advances underpinning antibody-mediated basophil responses and propose strategies for the treatment of basophil-associated disorders.
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