Zinc Promoted Urea Synthesis Using Carbonyldiimidazole as Carbonyl Source and Its Application for the Synthesis of Cariprazine

Abstract A convenient method has been developed for symmetrical and un‐symmetrical urea synthesis by using Carbonyldiimidazole (CDI) and recyclable activated zinc metal. This reaction is suitable for all types of amines and gives the desired urea products with good to excellent yield. The developed synthetic approach was employed for the synthesis of the Cariprazine drug.