Investigating the Mechanisms of Pazopanib-induced Hepatotoxicity:Insights from Network Toxicology, Microarray Analysis, andMachine Learning

This study enhances our understanding of the molecular mechanisms underlying pazopanib-induced hepatotoxicity, which is essential for developing protective strategies and therapeutic interventions. By integrating network toxicology, microarray analysis, and machine learning, this study provides a comprehensive framework for investigating the complex toxicological processes of specific compounds and offers insights that could improve the clinical applications and regulatory safety of targeted therapies.