光学相干层析成像
医学
眼科
金标准(测试)
视网膜
接收机工作特性
白内障手术
验光服务
放射科
内科学
作者
Elizabeth Yeu,John P. Berdahl,Preeya K. Gupta,Michael Patterson
出处
期刊:Journal of Cataract and Refractive Surgery
[Ovid Technologies (Wolters Kluwer)]
日期:2024-01-09
标识
DOI:10.1097/j.jcrs.0000000000001394
摘要
Purpose: To evaluate the sensitivity and specificity of swept-source optical coherence tomography (SS-OCT) biometer compared with the gold standard spectral-domain (SD-OCT) for detecting macular pathology in cataract patients. Setting: Study design: Prospective, cross-sectional, observational, examiner-masked. Methods: The study included 132 subjects aged ≥50 years, who underwent pre-cataract surgery work-up. All subjects underwent fixation check retinal scans using SS-OCT biometer (IOLMaster 700) as well as full macular scans using Cirrus SD-OCT. Three independent masked examiners evaluated the scans if they were normal or had a suspected pathology. Different measures of diagnostic accuracy were calculated for three examiners. Results: True positive rate (sensitivity) ranged from 71.1 (32/45) to 79.2% (42/53) and false negative rate was between 20.8 (11/53) to 28.9% (13/45) for the three examiners. True negative rate (specificity) ranged from 86.8 (59/68) to 94.1% (64/68) and false positive rate was between 5.9 (4/68) and 13.2% (9/68). The fitted receiver operating characteristic (ROC) area ranged from 0.83 to 0.95. Conclusion: Using retinal SS-OCT biometer scans as a replacement of the dedicated macular SD-OCT for screening or diagnosing macular health would not be appropriate due to its low sensitivity. SS-OCT biometer may potentially fail to identify approximately one-fourth of patients who actually have the disease. Therefore, the final decision on macular health should be based on the gold standard SD-OCT scans. When full macular SD-OCT scans are not accessible, the limited retinal scan information from SS-OCT biometer may still provide useful insights into the macular health.
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