废水
爆发
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
2019年冠状病毒病(COVID-19)
大流行
人口
生物
疾病
纳米孔
流行病学
病毒学
医学
环境卫生
环境科学
环境工程
传染病(医学专业)
内科学
材料科学
纳米技术
作者
Alžběta Dostálková,Kamila Zdeňková,Jana Bartáčková,Eliška Čermáková,Marina Kapisheva,Marco Antonio Lopez Marin,Vojtěch Kouba,Petr Sýkora,Martin Chmel,Oldřich Bartoš,Jiří Dresler,Kateřina Demnerová,Michaela Rumlová,Jan Bartáček
出处
期刊:Chemosphere
[Elsevier]
日期:2024-03-01
卷期号:351: 141162-141162
标识
DOI:10.1016/j.chemosphere.2024.141162
摘要
The early detection of upcoming disease outbreaks is essential to avoid both health and economic damage. The last four years of COVID-19 pandemic have proven wastewater-based epidemiology is a reliable system for monitoring the spread of SARS-CoV-2, a causative agent of COVID-19, in an urban population. As this monitoring enables the identification of the prevalence of spreading variants of SARS-CoV-2, it could provide a critical tool in the fight against this viral disease. In this study, we evaluated the presence of variants and subvariants of SARS-CoV-2 in Prague wastewater using nanopore-based sequencing. During August 2021, the data clearly showed that the number of identified SARS-CoV-2 RNA copies increased in the wastewater earlier than in clinical samples indicating the upcoming wave of the Delta variant. New SARS-CoV-2 variants consistently prevailed in wastewater samples around a month after they already prevailed in clinical samples. We also analyzed wastewater samples from smaller sub-sewersheds of Prague and detected significant differences in SARS-CoV-2 lineage progression dynamics among individual localities studied, e.g., suggesting faster prevalence of new variants among the sites with highest population density and mobility.
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