溃疡性结肠炎
拟杆菌
微生物学
结肠炎
生物
肠道菌群
拟杆菌科
脆弱类杆菌
细菌
医学
遗传学
免疫学
病理
抗生素
疾病
作者
Chen Wang,Hang Guo,Junying Bai,Leilei Yu,Fengwei Tian,Jianxin Zhao,Hao Zhang,Jianxin Zhao,Qixiao Zhai
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2024-01-01
摘要
Bacteroides is a common intestinal bacterium closely associated with host colitis. However, relevant studies have been focused on the genus level, which could not identify the major Bacteroides species associated with intestinal disease. Thus, we have evaluated the Bacteroides species structure in healthy people and mouse intestinal tracts and explored the change in major Bacteroides species during colitis development. The results demonstrated that B. uniformis with a high abundance in the intestinal tract of healthy people and mice may be a core species that contributes to colitis remission. The results of animal experiments reported that B. uniformis FNMHLBE1K1 (1K1) could alleviate the severity of colitis and enhance the expression of the tight junction protein occludin by regulating gut microbiota. Notably, the protective roles of 1K1 may be attributed to some specific genes. This study revealed that B. uniformis is a key microbe influencing the occurrence and development of colitis and it provides a scientific basis for screening the next generation of probiotics.
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