非酒精性脂肪肝
脂质代谢
脂解
脂肪生成
脂肪甘油三酯脂肪酶
脂肪变性
脂肪酶
内分泌学
新陈代谢
甘油三酯
脂肪酸代谢
油酸
化学
医学
脂肪肝
生物化学
脂肪组织
疾病
内科学
酶
胆固醇
作者
Kang Liu,Songsong Liu,Chou Wu,Yuwei Wang,Yurou Zhang,Jingsu Yu,Siqi Liu,Xiangling Li,Xinyu Qi,Songtao Su,Xinyi Qi,Lei Zhou,Yixing Li
标识
DOI:10.1016/j.intimp.2023.109948
摘要
Hepatic fat metabolism may be altered in the context of overnutrition and obesity, often resulting in the accumulation of triglycerides in hepatocytes and leading to nonalcoholic fatty liver disease (NAFLD). Natural plant alkaloids have demonstrated great potential for the prevention and treatment of NAFLD. However, the role of rhynchophylline (RHY) in lipid metabolism is not clear. We explored the role of RHY in lipid metabolism in cells treated with oleic and palmitic acids to mimic high-fat diet (HFD) conditions. RHY attenuated oleic and palmitic acid-induced increases in triglyceride accumulation in HepG2, AML12, and LMH cells. RHY also increased energy metabolism and reduced oxidative stress. We further investigated the effect of RHY on hepatic lipid metabolism in mice fed an HFD including 40 mg/kg RHY. RHY alleviated hepatic steatosis, reduced fat deposition, promoted energy metabolism, and improved glucose metabolism. We investigated the mechanism responsible for this activity by docking with key proteins of lipid metabolism disorders using Discovery Studio software, which showed that RHY interacted well with lipases. Finally, we found that adding RHY promoted lipase activity and lipolysis. In conclusion, RHY ameliorated HFD-induced NAFLD and its complications by increasing lipase activity.
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