以兹提米比
胆固醇
医学
冠心病
胆固醇合成
甾醇
脂质代谢
药理学
疾病
生物信息学
内科学
生物
生物化学
酶
还原酶
作者
Renshuai Zhang,Wenjing Liu,Jun Zeng,Jingsen Meng,Lingyu Shi,Shanbo Yang,Jing Chang,Chao Wang,Kunyue Xing,Jialian Wen,Ning Liu,Bing Liang,Dongming Xing
标识
DOI:10.1016/j.biopha.2022.113732
摘要
NPC1L1 is a crucial protein involved in sterol lipid absorption and has been shown to play an important role in intestinal cholesterol absorption. Hypercholesterolemia is a significant risk factor for cardiovascular diseases such as coronary heart disease. Screening of NPC1L1 inhibitors is critical for gaining a full understanding of lipid metabolism, developing new cholesterol-lowering medicines, and treating cardiovascular diseases. This work summarized existing methodologies for screening NPC1L1 inhibitors and evaluated their challenges, and will assist the development of novel cholesterol-lowering medications and therapeutic strategies for hypercholesterolemia and other cholesterol-related metabolic disorders.
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