Association of the triglyceride glucose index with insulin resistance and subclinical atherosclerosis in psoriasis: An observational cohort study

To the Editor: Psoriasis is a chronic inflammatory disease that affects 2% of adults. 1 Rachakonda T.D. Schupp C.W. Armstrong A.W. Psoriasis prevalence among adults in the United States. J Am Acad Dermatol. 2014; 70: 512-516https://doi.org/10.1016/j.jaad.2013.11.013 Abstract Full Text Full Text PDF PubMed Scopus (617) Google Scholar In psoriasis, insulin resistance is elevated and associated with increased noncalcified coronary burden (NCB) via coronary computed tomography angiography, a measure of subclinical atherosclerosis. 2 Teklu M. Zhou W. Kapoor P. et al. Metabolic syndrome and its factors are associated with noncalcified coronary burden in psoriasis: an observational cohort study. J Am Acad Dermatol. 2021; 84: 1329-1338https://doi.org/10.1016/j.jaad.2020.12.044 Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar The triglyceride glucose index (TyG index) is a simple, widely accessible surrogate for insulin resistance that associates with cardiovascular events 3 Li S. Guo B. Chen H. et al. The role of the triglyceride (triacylglycerol) glucose index in the development of cardiovascular events: a retrospective cohort analysis. Scientific Rep. 2019; 9: 7320https://doi.org/10.1038/s41598-019-43776-5 Crossref PubMed Scopus (85) Google Scholar and predicts some metabolic abnormalities superior to the individual components in the index. 4 Navarro-González D. Sánchez-Íñigo L. Pastrana-Delgado J. Fernández-Montero A. Martinez J.A. Triglyceride-glucose index (TyG index) in comparison with fasting plasma glucose improved diabetes prediction in patients with normal fasting glucose: the vascular-metabolic CUN cohort. Prev Med. 2016; 86: 99-105https://doi.org/10.1016/j.ypmed.2016.01.022 Crossref PubMed Scopus (207) Google Scholar No studies have characterized the TyG index in quantifying insulin resistance and NCB in patients with psoriasis. We explored the efficacy of the TyG index in assessing cardiometabolic risk and its association with subclinical atherosclerosis in psoriasis.