窦卵泡
卵巢储备
抗苗勒氏激素
不育
卵巢早衰
医学
妇科
生育率
人口
多囊卵巢
卵巢
保持生育能力
卵母细胞
怀孕
男科
激素
内科学
生物
胚胎
胰岛素
胰岛素抵抗
遗传学
环境卫生
细胞生物学
作者
Didier Dewailly,Joop S.E. Laven
出处
期刊:European journal of endocrinology
[Bioscientifica]
日期:2019-12-01
卷期号:181 (6): D45-D51
被引量:38
摘要
In women, the anti-Müllerian hormone (AMH) is secreted by the granulosa cells of growing follicles. Its measurement is strongly correlated with antral follicle count and represents a reliable marker of ovarian reserve. It also has the advantage of being highly reproducible since it has little variation within and between cycles. However, although it seems to be a good quantitative reflection of the ovarian reserve, it does not assess oocyte or embryo quality. This drawback precludes any good prediction of female fertility in the general population as well as in specific subgroups of patients. However, the AMH assay can become an indirect marker of the remaining female fertile years in some cases such as in those women who are at risk for premature ovarian failure or in those suffering from polycystic ovary syndrome. Its interest is no more to be proven in assisted reproductive technology where it is a valuable aid to the choice of the proposed techniques, ovarian stimulation protocols and gonadotropin dosage. AMH is finally very informative in monitoring cancer patients having received gonadotoxic drugs or having undergone mutilating ovarian surgeries. In conclusion, although it cannot be considered as a reliable predictor of pregnancy in women, AMH is now a useful tool in the management and treatment of female infertility.
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