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Light emitting fabrics for PDT: technology and results of clinical studies

光化性角化病 同种类的 材料科学 光动力疗法 光学 皮肤病科 光电子学 光源 同质性(统计学) 生物医学工程 医学 化学 病理 计算机科学 物理 有机化学 机器学习 热力学 基底细胞
作者
Serge Mordon,Elise Thécua,F. Lecomte,Anne‐Sophie Vignion‐Dewalle,Pascal Deleporte,Cyril Maire,Henry Abi Rached,C. Vicentini,Theresa Hommel,Rolf‐Markus Szeimies,Laurent Mortier
出处
期刊:17th International Photodynamic Association World Congress 卷期号:: 175-175
标识
DOI:10.1117/12.2524874
摘要

A homogeneous and reproducible fluence rate delivery during clinical PDT plays a determinant role in preventing underor overtreatment. In Dermatology, topical PDT has been carried out with a wide variety of light sources delivering a broad range of light doses. However, these light sources do not deliver a uniform light distribution on the skin due to their structure and morphology and the complexities of the human anatomy. The development of a flexible light source able to generate uniform light on all its surface would considerably improve the homogeneity of light delivery. The integration of plastic optical fibers (POF) into textile structures offers an interesting alternative. The homogeneous light side-emission from the fabric is obtained by controlling the bending angles of POF inside the LEF due to specific architecture generated by knitting of textile structure. LEF of different surfaces can be easily manufactured (up to 500cm2 The LEF thickness is less than 1 mm. The mean irradiance is typically 2.5 mW.cm-2. W-1 with heterogeneity of 12.5% at any point of the LEF. The temperature elevation remains below 1°C. These LEF were evaluated in Dermatology for the treatment of Actinic Keratosis. Two clinical evaluation were performed. The first one was a monocentric, randomized, controlled, phase II clinical study (ClinicalTrials.gov Identifier: NCT03076918). Twenty five (25) patients with grade I-II actinic keratosis (AK) of the forehead and scalp were treated with methyl aminolevulinate photodynamic therapy in two symmetrical areas. One area was treated with the conventional LED panel (154 AK), whereas the other area was treated with the LEF device (156 AK). The second clinical was performed in 2 centers. This new LEF device was a more ergonomic and compact version of the original system developed for FLEXIPDT. In this clinical study (ClinicalTrials.gov Identifier: NCT03076892), the irradiance has been reduced from 12.3 mW/cm2 to 1.3 mW/cm2 and the light dose from 37 J/cm2 to 12 J/cm2 . Compared to Conventional PDT, the 2 protocols clearly shown that LEF are equivalent and even superior in terms of efficacy for treating AK of the forehead and scalp. However, the use of LEF resulted in much lower pain scores and fewer adverse effects. In conclusion, thanks to LEF, PDT of AK can be conducted in all weather conditions, in any geographic location, year-round and benefits from the optimal adaptability of the flexible, light-emitting, fabrics to the treatment area. At last, LEF can be easily can be easily manufactured in large series.

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