内大麻素系统
致电离效应
神经科学
功能(生物学)
脂质信号
大麻素受体
生物
受体
细胞生物学
生物化学
NMDA受体
兴奋剂
作者
Jessica K. Cao,Joshua S. Kaplan,Nephi Stella
标识
DOI:10.1016/j.tips.2019.02.002
摘要
The endocannabinoid (eCB) signaling system modulates neurotransmission and inflammation, among other physiological functions. Its newest member, α/β-hydrolase domain-containing 6 (ABHD6), has emerged as a promising therapeutic target to treat several devastating diseases, including epilepsy. Here, we review the molecular mechanisms that mediate and control eCB signaling and, within it, the specific role of ABHD6. We also discuss how ABHD6 controls the abundance of additional lipids and the trafficking of ionotropic receptors to plasma membranes. We finish with several unexplored questions regarding this novel enzyme. Our current understanding of the molecular mechanism and biological function of ABHD6 provides a strong foundation for the development of small-molecule therapeutics to treat devastating diseases.
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