血管平滑肌
材料科学
表面改性
选择性
儿茶酚
一氧化氮
表面工程
铜
纳米技术
催化作用
化学
生物化学
有机化学
生物
冶金
物理化学
内分泌学
平滑肌
作者
Xiangyang Li,Jing‐Xia Liu,Tong Yang,Hua Qiu,Lei Lü,Qiufen Tu,Kaiqing Xiong,Nan Huang,Zhilu Yang
出处
期刊:Biomaterials
[Elsevier]
日期:2020-05-01
卷期号:241: 119904-119904
被引量:54
标识
DOI:10.1016/j.biomaterials.2020.119904
摘要
Specific selectivity of vascular cells and antithrombogenicity are crucial factors for the long-term success of vascular implants. In this work, a novel concept of mussel-inspired “built-up” surface chemistry realized by sequential stacking of a copper-dopamine network basement, followed by a polydopamine layer is introduced to facilitate the combination of nitric oxide (NO) catalysis and vascular cell selectivity. The resultant “built-up” film allowed easy manipulation of the content of copper ions and the density of catechol/quinone groups, facilitating the multifunctional surface engineering of vascular devices. For example, the chelated copper ions in the copper-dopamine network endow a functionalized vascular stent with a durable release of NO via catalytic decomposition of endogenous S-nitrosothiol. Meanwhile, the catechol/quinone groups on the film surface allow the facile, secondary grafting of the REDV peptide to develop a selectivity for vascular cells, as a supplement to the functions of NO. As a result, the functionalized vascular stent perfectly combines the functions of NO and REDV, showing excellent antithrombotic properties and competitive selectivity toward the endothelial cells over the smooth muscle cells, hence impressively promotes re-endothelialization and improves anti-restenosis in vivo. Therefore, the first mussel-inspired “built-up” surface chemistry can be a promising candidate for the engineering of multifunctional surfaces.
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