线粒体
氧化应激
细胞生物学
程序性细胞死亡
线粒体ROS
NADPH氧化酶
TXNIP公司
癌细胞
细胞色素c
作者
Juan-Hua Quan,Fei Fei Gao,Jia-Qi Chu,Guang-Ho Cha,Jae-Min Yuk,Weiyun Wu,Young-Ha Lee
标识
DOI:10.2217/nnm-2021-0098
摘要
Aim: To investigate the anticancer mechanisms of silver nanoparticles (AgNPs) in colorectal cancer. Methods: Anticancer effects of AgNPs were determined in colorectal cancer HCT116 cells and xenograft mice using cellular and molecular methods. Results: AgNPs induced mitochondrial reactive oxygen species production, mitochondrial dysfunction and endoplasmic reticulum (ER) stress responses through NOX4 and led to HCT116 cell apoptosis. Pretreatment with DPI or 4-PBA significantly inhibited mitochondrial reactive oxygen species production, apoptosis, ER stress response, NOX4 expression and mitochondrial dysfunction in AgNP-treated HCT116 cells. AgNPs also significantly suppressed HCT116 cell-based xenograft tumor growth in nude mice by inducing apoptosis and ER stress responses. Conclusion: AgNPs exert anticancer effects against colorectal cancer via ROS- and ER stress-related mitochondrial apoptosis pathways.
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