亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Asciminib as a new option in the treatment of chronic myeloid leukemia

达沙替尼 医学 髓系白血病 血液学 尼罗替尼 内科学 酪氨酸激酶抑制剂 肿瘤科 伊马替尼 癌症
作者
Betül İbiş,Mario Tiribelli,Ahmet Emre Eşkazan
出处
期刊:Future Oncology [Future Medicine]
卷期号:17 (36): 5003-5005 被引量:8
标识
DOI:10.2217/fon-2021-1174
摘要

Future OncologyVol. 17, No. 36 EditorialAsciminib as a new option in the treatment of chronic myeloid leukemiaBetül İbiş, Mario Tiribelli & Ahmet Emre EşkazanBetül İbiş https://orcid.org/0000-0002-6148-6177Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey, Mario Tiribelli https://orcid.org/0000-0001-9449-2621Division of Hematology and Blood and Marrow Transplantation, Department of Medical Area, University of Udine, Udine, Italy & Ahmet Emre Eşkazan *Author for correspondence: Tel.: +90 533 722 7376; E-mail Address: emre.eskazan@iuc.edu.trhttps://orcid.org/0000-0001-9568-0894Division of Hematology, Department of Internal Medicine, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, TurkeyPublished Online:18 Nov 2021https://doi.org/10.2217/fon-2021-1174AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: ABL myristoyl pocketasciminibchronic myeloid leukemiaT315Ityrosine kinase inhibitorReferences1. Tiribelli M, Eskazan AE. Tyrosine kinase inhibitor sequencing in patients with chronic myeloid leukemia. Oncol. Ther. 7(2), 95–100 (2019).Crossref, Medline, Google Scholar2. Ibrahim AR, Paliompeis C, Bua M et al. Efficacy of tyrosine kinase inhibitors (TKIs) as third-line therapy in patients with chronic myeloid leukemia in chronic phase who have failed 2 prior lines of TKI therapy. Blood 116(25), 5497–5500 (2010).Crossref, Medline, CAS, Google Scholar3. Ongoren S, Eskazan AE, Suzan V et al. Third-line treatment with second-generation tyrosine kinase inhibitors (dasatinib or nilotinib) in patients with chronic myeloid leukemia after two prior TKIs: real-life data on a single center experience along with the review of the literature. Hematology 23(4), 212–220 (2018).Crossref, Medline, CAS, Google Scholar4. Chan O, Talati C, Isenalumhe L et al. Side-effects profile and outcomes of ponatinib in the treatment of chronic myeloid leukemia. Blood Adv. 4(3), 530–538 (2020).Crossref, Medline, CAS, Google Scholar5. Özgür Yurttaş N, Eşkazan AE. Novel therapeutic approaches in chronic myeloid leukemia. Leuk. Res. 91, 106337 (2020).Crossref, Medline, Google Scholar6. Wylie AA, Schoepfer J, Jahnke W et al. The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1. Nature 543(7647), 733–737 (2017).Crossref, Medline, CAS, Google Scholar7. Schuld P, Grzesiek S, Schlotte J et al. Structural and biochemical studies confirming the mechanism of action of asciminib, an agent specifically targeting the ABL myristoyl pocket (STAMP). Blood. 136(Suppl. 1), 34–35 (2020).Crossref, Google Scholar8. Hughes TP, Mauro MJ, Cortes JE et al. Asciminib in chronic myeloid leukemia after ABL kinase inhibitor failure. N. Engl. J. Med. 381(24), 2315–2326 (2019).Crossref, Medline, CAS, Google Scholar9. Rea D, Mauro MJ, Boquimpani C et al. A phase 3, open-label, randomized study of asciminib, a STAMP inhibitor, vs bosutinib in CML after ≥2 prior TKIs. Blood. doi:10.1182/blood.2020009984 (2021).Crossref, Google Scholar10. Cortes JE, Hughes TP, Mauro MJ et al. Asciminib, a first-in-class STAMP inhibitor, provides durable molecular response in patients (pts) with chronic myeloid leukemia (CML) harboring the T315I mutation: primary efficacy and safety results from a phase 1 trial. Blood. 136(Suppl. 1), 47–50 (2020).Crossref, Google Scholar11. Garcia-Gutiérrez V, Luna A, Alonso-Dominguez JM et al. Safety and efficacy of asciminib treatment in chronic myeloid leukemia patients in real-life clinical practice. Blood Cancer J. 11(2), 16 (2021).Crossref, Medline, Google Scholar12. Eşkazan AE. Asciminib in chronic myeloid leukemia: many questions still remain to be answered. Blood Cancer J. 11(4), 81 (2021).Crossref, Medline, Google Scholar13. Eide CA, Zabriskie MS, Savage Stevens SL et al. Combining the allosteric inhibitor asciminib with ponatinib suppresses emergence of and restores efficacy against highly resistant BCR-ABL1 mutants. Cancer Cell 36(4), 431–443.e5 (2019).Crossref, Medline, CAS, Google Scholar14. Cortes J, Lang F, Kim DW et al. Combination therapy using asciminib plus imatinib (IMA) in patients (PTS) with chronic myeloid leukemia (CML): results from a phase 1 study. HemaSphere. 3(S1), 397 (2019).Crossref, Google Scholar15. Mauro MJ, Kim DW, Cortes J et al. Combination of asciminib plus nilotinib (NIL) or dasatinib (DAS) in patients (PTS) with chronic myeloid leukemia (CML): Results from a phase 1 study. HemaSphere. 3(S1), 398–398 (2019).Crossref, Google Scholar16. Hall KH, Brooks A, Waller EK. Overcoming TKI resistance in a patient with chronic myeloid leukemia using combination BCR-ABL inhibition with asciminib and bosutinib. Am. J. Hematol. 96(8), e293–e295 (2021).Crossref, Medline, CAS, Google Scholar17. Frontline asciminib combination in chronic phase CML (CMLXI) (2021). https://clinicaltrials.gov/ct2/show/NCT03906292Google Scholar18. Study of efficacy and safety of asciminib in combination with imatinib in patients with chronic myeloid leukemia in chronic phase (CML-CP) (2021). https://clinicaltrials.gov/ct2/show/NCT03578367Google Scholar19. ABL001 for the treatment of chronic myeloid leukemia in patients who are on therapy with tyrosine kinase inhibitor (2021). https://clinicaltrials.gov/ct2/show/NCT04216563Google Scholar20. Asciminib in monotherapy for chronic myeloid leukemia in chronic phase (CML-CP) with and without T315I mutation (AIM4CML) (2021). https://clinicaltrials.gov/ct2/show/NCT04666259Google Scholar21. PABL001 + dasatinib + prednisone in BCR-ABL+ B-ALL or CML (2021). https://clinicaltrials.gov/ct2/show/NCT03595917Google ScholarFiguresReferencesRelatedDetailsCited ByGuidelines for the treatment of chronic myeloid leukemia from the NCCN and ELN: differences and similarities5 September 2022 | International Journal of Hematology, Vol. 117, No. 1Asciminib monotherapy for newly diagnosed chronic myeloid leukemia in chronic phase: the ASC4FIRST phase III trialJorge E Cortes, Andreas Hochhaus, Naoto Takahashi, Richard A Larson, Ghayas C Issa, Felice Bombaci, Nicholas Ramscar, Sophie Ifrah & Timothy P Hughes16 December 2022 | Future Oncology, Vol. 18, No. 38Patient characteristics and management practices in chronic myeloid leukemia in Turkey: reflections from an expert meeting4 March 2022 | Expert Review of Hematology, Vol. 15, No. 2 Vol. 17, No. 36 eToC Sign up Follow us on social media for the latest updates Metrics Downloaded 195 times History Received 14 September 2021 Accepted 15 September 2021 Published online 18 November 2021 Published in print December 2021 Information© 2021 Future Medicine LtdKeywordsABL myristoyl pocketasciminibchronic myeloid leukemiaT315Ityrosine kinase inhibitorFinancial & competing interests disclosureM Tiribelli has received speaker bureau and advisory board honoraria from Novartis, Bristol Myers Squibb, Incyte and Celgene outside the present study. AE Eşkazan has received advisory board honoraria from Novartis and Pfizer. AE Eşkazan has also received speaker bureau honoraria from Novartis, Bristol Myers Squibb and Pfizer outside the present study. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
量子星尘发布了新的文献求助10
10秒前
zyz发布了新的文献求助30
49秒前
科研通AI2S应助科研通管家采纳,获得10
52秒前
lzx发布了新的文献求助10
52秒前
fanboyz完成签到 ,获得积分10
1分钟前
科研通AI2S应助zyz采纳,获得10
2分钟前
李健的小迷弟应助zyz采纳,获得20
2分钟前
XX完成签到,获得积分10
2分钟前
领导范儿应助Ximao1008采纳,获得10
2分钟前
3分钟前
3分钟前
Ximao1008发布了新的文献求助10
3分钟前
XX发布了新的文献求助10
3分钟前
慕青应助achulw采纳,获得10
3分钟前
Ximao1008完成签到,获得积分20
3分钟前
3分钟前
achulw发布了新的文献求助10
3分钟前
科研通AI2S应助achulw采纳,获得10
3分钟前
3分钟前
_响_发布了新的文献求助10
3分钟前
4分钟前
SciGPT应助小彭采纳,获得20
4分钟前
MchemG完成签到,获得积分0
4分钟前
4分钟前
小彭发布了新的文献求助20
4分钟前
Kashing完成签到,获得积分10
4分钟前
研友_VZG7GZ应助hzc采纳,获得10
5分钟前
胖小羊完成签到 ,获得积分10
5分钟前
上官若男应助ll采纳,获得10
5分钟前
6分钟前
ll发布了新的文献求助10
6分钟前
zsmj23完成签到 ,获得积分0
7分钟前
ll发布了新的文献求助10
7分钟前
8分钟前
大个应助KEYANMINGONG采纳,获得10
8分钟前
科研通AI2S应助科研通管家采纳,获得10
8分钟前
8分钟前
KEYANMINGONG发布了新的文献求助10
9分钟前
9分钟前
量子星尘发布了新的文献求助30
9分钟前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Einführung in die Rechtsphilosophie und Rechtstheorie der Gegenwart 1500
Cowries - A Guide to the Gastropod Family Cypraeidae 1200
Handbook of Milkfat Fractionation Technology and Application, by Kerry E. Kaylegian and Robert C. Lindsay, AOCS Press, 1995 1000
Reflections of female probation practitioners: navigating the challenges of working with male offenders 500
Probation staff reflective practice: can it impact on outcomes for clients with personality difficulties? 500
PRINCIPLES OF BEHAVIORAL ECONOMICS Microeconomics & Human Behavior 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 内科学 生物化学 物理 计算机科学 纳米技术 遗传学 基因 复合材料 化学工程 物理化学 病理 催化作用 免疫学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 5031687
求助须知:如何正确求助?哪些是违规求助? 4266169
关于积分的说明 13298686
捐赠科研通 4075616
什么是DOI,文献DOI怎么找? 2229106
邀请新用户注册赠送积分活动 1237662
关于科研通互助平台的介绍 1162674