光热治疗
纳米颗粒
胶体
单宁酸
没食子酸
多酚
粒径
化学工程
光热效应
化学
材料科学
纳米技术
有机化学
工程类
抗氧化剂
物理化学
作者
Jing Qin,Guohai Liang,Dong Cheng,Yining Liu,Xiaoran Cheng,Pengkun Yang,Na Wu,Yongxi Zhao,Jing Wei
标识
DOI:10.1016/j.jcis.2021.02.082
摘要
Iron-polyphenol nanoparticles are usually prepared with nontoxic plant polyphenols as a main building block, which are an emerging photothermal agent for photothermal therapy. However, till now, few works have been made on the controllable synthesis of iron-polyphenol nanoparticles with tunable composition, as well as investigation of the relationship between material composition and photothermal property. In the present study, iron-polyphenol colloidal nanoparticles with tunable diameter (21–303 nm) and ion content (9.2–97.6 mg/g), as well as high colloidal stability are successfully synthesized using different polyphenols (such as tannic acid, epigallocatechin gallate, gallic acid, epicatechin and proanthocyanidin) as a ligand. In addition, photothermal performance is highly dependent on the organic ligand, iron content and particle size. Higher iron content and smaller diameter can contribute to higher photothermal performance. The iron-polyphenol nanoparticles with the optimal iron content and particle size are selected as a photothermal agent. They can effectively inhibit the tumour growth in vivo. The current work demonstrates a general synthesis strategy for iron-polyphenol colloidal nanoparticles with tailorable composition and clarifies the relationship between material composition and photothermal performance. Moreover, it is conductive to the rational design of polyphenol-based photothermal agents for theranostic applications.
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