美金刚
自闭症谱系障碍
氯胺酮
金刚烷胺
谷氨酸的
NMDA受体
心理学
谷氨酸受体
自闭症
敌手
萧条(经济学)
精神科
医学
麻醉
神经科学
内科学
受体
经济
宏观经济学
作者
Logan Wink,Anne O’Melia,Rebecca C. Shaffer,Ernest V. Pedapati,Katherine Friedmann,Tori L. Schaefer,Craig A. Erickson
标识
DOI:10.4088/jcp.13cr08917
摘要
Article Abstract †‹Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text. Ketamine, a noncompetitive antagonist at the N-methyl-d-aspartate glutamate receptor, has been demonstrated in controlled clinical trials to rapidly decrease symptoms of depression in adults via intravenous infusion and has demonstrated promising results in an uncontrolled trial of intranasal infusion in adolescents with bipolar disorder. Other glutamatergic modulators, including d-cycloserine, amantadine, and memantine, have been the focus of drug development targeting core social impairment in autism spectrum disorder (ASD). However, to date, there have been no reports of ketamine treatment in individuals with ASD.
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