Acta Crystallographica, Section D, devoted to all aspects of biological crystallography, has appeared monthly since 1999. The annual content has been approximately 170 research papers and 200 crystallization papers. Figures in color are provided free of charge. All authors are asked to confirm that they have seen the final manuscript. Submitted articles reflect advances in the field. Larger structures are now described in more detail and at higher resolution. Improvements are evident in crystallization protocols, methods for solving the phase problem, and refinement of macromolecular structures. A welcome component is the addition of the Proceedings of CCP4 Study Weekends, focused in 1999 on 'Data collection and processing,' in 2000 on 'Lowresolution phasing' and in 2001 on 'Molecular replacement and its relatives.' 'Crystallization papers' indicate what people are working on. The three Crystallization Co-editors are Naomi Chayen, Adriana Zagari and Marc Pusey. We are evaluating the impact of 'high throughput' macromolecular crystallography on our journal.