Tumor specific delivery with redox-triggered mesoporous silica nanoparticles inducing neovascularization suppression and vascular normalization

Redox-responsive mesoporous silica nanoparticles with enlarged pores (denoted as MSN-siRNA/CrPEI) were designed by immobilizing polyethylenimine (PEI)viaintermediate linkers of disulfide bonds onto the MSNs as caps for redox-responsive intracellular gene delivery.