Surface modified poly(methyl methacrylate) with 1-methyl- 2-methacrylamidoethyl phosphorylcholine moiety

A series of poly(methyl methacrylate) [poly(MMA)] microspheres covered with the 1-methyl-2-methacrylamidoethyl phosphorylcholine (MAPC) moiety, poly(MAPC-co-MMA), were prepared by emulsifier-free emulsion copolymerization of methyl methacrylate (MMA) and MAPC using potassium peroxodisulfate (KPS) or 2,2′-azobis[2-(imidazolin-2-yl)propane] dihydrochloride (ABIP) as initiators. The ζ-potentials of the particles are –72 to –26 mV and 0 to 27 mV for poly(MAPC-co-MMA) produced by KPS and ABIP, respectively. Poly(MAPC-co-MMA) suppresses the adsorption of albumin, γ-globulin, and fibrinogen more than poly(MMA) as the control. From XPS measurements the MAPC moiety and the fragments of the initiator are located on the surface of the polymer films prepared from poly(MAPC-co-MMA). Egg yolk lecithin adsorbs on the surface of the films, and an organized adsorption layer of lipid, i. e., a hydrogel layer with an analogous structure to biomembrane, is formed.