Boron Imidazolate Framework‐Derived Porous Carbon Nanospheres for Dual‐Mode Bioimaging‐Guided Photothermal/Sonodynamic Synergistic Cancer Therapy

Abstract Development of efficient nanotherapeutic agents to enhance anticancer therapeutic effects is challenging. In this study, photo/sono‐dual‐responsive boron imidazolate framework‐derived single‐component porous carbon nanospheres (PCNSs) are successfully developed for dual‐mode bioimaging‐guided photothermal/sonodynamic (PTT/SDT) synergistic therapy for triple‐negative breast cancer. The PCNS not only exhibits satisfactory and excellent photothermal conversion ability under near‐infrared laser irradiation but also demonstrates a promising capability as an efficient sonosensitizer to generate cytotoxic reactive oxygen species through inertial cavitation in response to low‐intensity ultrasound stimulation. The outstanding photothermal effect enhances the blood flow in tumor tissues and thus improves the oxygen supply, helping to achieve a remarkable synergistic therapeutic effect in the PTT/SDT synergistic therapy without any tumor recurrence or systemic toxicity. Interestingly, the PCNS enables the precise visualization of solid tumors using contrast‐enhanced ultrasound and photothermal dual‐modal bioimaging techniques. Overall, this study provides valuable insights in developing all‐in‐one theranostic nanoplatforms for the clinical treatment of triple‐negative breast cancer.