医学
肌萎缩
脂肪肝
内科学
血脂异常
体质指数
生物电阻抗分析
胃肠病学
瞬态弹性成像
肝硬化
糖尿病
腰围
代谢综合征
瘦体质量
疾病
内分泌学
肥胖
肝纤维化
体重
作者
Joana Rigor,Raquel Vasconcelos,Rogério Lopes,Teresa Moreira,Pedro Barata,Daniela Martins‐Mendes
出处
期刊:Minerva gastroenterology
[Edizioni Minerva Medica]
日期:2023-08-01
卷期号:69 (3)
被引量:6
标识
DOI:10.23736/s2724-5985.22.03097-2
摘要
Non-alcoholic fatty liver disease (NAFLD) is a rising global health issue. The influence of muscle in its pathophysiology has recently gained attention. Our aim was to investigate the association of low muscle mass, strength, and performance with the presence and severity of NAFLD.Patients with metabolic syndrome followed in an outpatient clinic, were consecutively included, between April 1st and December 31st, 2019. Abdominal ultrasound for the diagnosis of NAFLD, NAFLD fibrosis score (NFS) and Fibrosis-4 Index (FIB-4) for determination of significant fibrosis, dual-energy X-ray absorptiometry for calculation of skeletal muscle index (SMI = appendicular skeletal mass / weight x100) and sarcopenic index (SI = appendicular skeletal mass / Body Mass Index), and the Short Physical Performance Battery for muscle strength and performance assessment were performed. Sarcopenia was defined as low muscle strength and low SMI or SI.A total of 157 patients were included, of which 68.8% had NAFLD, 66.2% low SMI, 50.3% low SI, 16.6% low performance and 11.5% low strength. In patients with NAFLD, prevalence of significant fibrosis by NFS was 15.7%. Low SMI was associated with presence of NAFLD when adjusted for age, sex, type 2 diabetes mellitus, hypertension, and dyslipidemia, but not for body mass index and waist circumference. Low SMI, low SI, and sarcopenia were associated with significant fibrosis in univariate analysis; the small number of events precluded a multivariable analysis.Low SMI was associated with NAFLD independently of demographics and comorbidities but not of other parameters of body composition. This contrasts with most studies published on this matter.
科研通智能强力驱动
Strongly Powered by AbleSci AI