威尼斯人
医学
氟达拉滨
内科学
慢性淋巴细胞白血病
肿瘤溶解综合征
中性粒细胞减少症
IGHV@
奥比努图库单抗
队列
肿瘤科
淋巴瘤
发热性中性粒细胞减少症
淋巴细胞增多症
胃肠病学
白血病
化疗
环磷酰胺
作者
Andrew W. Roberts,Matthew S. Davids,John M. Pagel,Brad S. Kahl,Soham D. Puvvada,John F. Gerecitano,Thomas J. Kipps,Mary Ann Anderson,Jennifer R. Brown,Lori A. Gressick,Shekman Wong,Martin Dunbar,Ming Zhu,Monali Desai,Elisa Cerri,Sari H. Enschede,Rod Humerickhouse,William G. Wierda,John F. Seymour
标识
DOI：10.1056/nejmoa1513257
摘要
New treatments have improved outcomes for patients with relapsed chronic lymphocytic leukemia (CLL), but complete remissions remain uncommon. Venetoclax has a distinct mechanism of action; it targets BCL2, a protein central to the survival of CLL cells.
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