Correlation of senescence-related gene FEN1 on neuroblastoma progression and cisplatin chemotherapy sensitivity

Bioinformatics and sequencing analyses indicate that the senescence-related gene FEN1 is significantly associated with cisplatin sensitivity and adverse prognosis in pediatric NB. FEN1 plays a pivotal role in regulating NB cell proliferation, invasion, and migration, thereby facilitating cancer progression. Furthermore, it influences cisplatin sensitivity through its effects on cellular senescence. FEN1 inhibitors demonstrate potential both as monotherapies and in conjunction with cisplatin, suggesting that targeting FEN1 may be represent a valuable strategy for improving outcomes in high-risk NB patients.