Shape Memory Polyurethane Foams With Tunable Mechanical Properties and Radiation Tolerance for Breast Repair and Reconstruction

ABSTRACT This study developed a shape memory polyurethane foam (SM‐PUF) with tunable mechanical properties and exceptional radiation tolerance for potentially implanting tissue defects after mastectomy. The PUFs were synthesized via an in situ foaming strategy using water as a foaming agent, incorporating 4,4′‐diphenylmethane diisocyanate (MDI) as the rigid segment and both polyoxytetramethylene glycol and polycaprolactone as the soft segment. The resultant PUFs possess an open‐cell structure with a pore size of 30 ~ 800 μm, which achieves a compressive stress of 0.04 MPa under 70% compression strain and a tensile elongation of 667.9%. PUFs exhibit body temperature (37°C)‐responsive softening and shape memory abilities, with recovery and fixation ratios reaching 88% and 98%, respectively. It was verified that PUFs can resist 40 Gy radiotherapy without changing their mechanical properties and biocompatibility. This study introduces an innovative approach to produce customizable foam for the reconstruction of implant prostheses for the breast.