Recurrent miscarriage is a complex reproductive health problem when a woman suffers spontaneous miscarriage during two or more consecutive pregnancies. Recurrent miscarriage is a distressing condition in which immune factors play an important role. The immune system has an impact on the processes of embryo implantation, growth and development, and immune abnormalities may lead to rejection of the foetus or difficulties in implantation, thus triggering recurrent miscarriage. Therefore, the role of immune factors in recurrent miscarriages and advances in immunotherapy will open up more possibilities and hopefully bring new reproductive hopes and possibilities to couples who suffer from recurrent miscarriages.