Effects of nano and microplastics on the reproduction system: In vitro and in vivo studies review

Microplastics (MPs) and nanoplastics (NPs), as their name suggest, are tiny plastic particles. The negative impact of MPs as an emerging pollutant on humans is not hidden from anyone. Recent research on how this pollutant affects the reproductive system and how it enters the blood, placenta, and semen has attracted the attention of scientists. This review study deals with the reproductive toxicity of MPs particles in terrestrial animals, aquatic animals, soil fauna, human cells, and human placenta. In vitro and in vivo animal studies showed that MPs can lead to reduced fertility in men, reduced ovarian capacity, apoptosis of granulosa cells, or even reduced sperm motility. They cause oxidative stress and cell apoptosis and inflammatory effects. The results of these animal studies show that MPs may have similar effects on the human reproductive system. However, not much research has been done on human reproductive toxicity by MPs. Therefore, special attention should be paid to the toxicity of the reproductive system by MPs. The purpose of this comprehensive study is to express the importance of the impact of MPs on the reproductive system. These results provide new insight into the potential dangers of MPs.