银屑病
伊米奎莫德
芳香烃受体
角质形成细胞
医学
免疫学
病态的
炎症
发育不良
下调和上调
机制(生物学)
癌症研究
化学
病理
转录因子
体外
哲学
认识论
基因
生物化学
作者
Xingyu Zhu,Ruomei Han,Xiaoxue Tian,Markus Hochgerner,Hui Li,Jiucun Wang,Jingjing Xia
摘要
Tapinarof is an aryl hydrocarbon receptor (AHR) ligand which is used to treat plaque psoriasis in adults. However, the underlying mechanism is not yet fully understood. In this study, we applied two of the most studied psoriasis mouse models: topical application of imiquimod (IMQ) and subcutaneous injection of IL-23. Although both models successfully induced psoriasis-like lesions in mice, tapinarof had a completely opposite effect on the two models. Tapinarof decreased the expression of multiple essential cytokines involved in the pathological IL-23/IL-17/IL-22 axis and ameliorated IMQ-induced psoriatic dermatitis, inhibiting keratinocyte proliferation and abnormal differentiation. However, in the IL-23-injection-model, tapinarof instead aggravated the disease. Here, tapinarof increased epidermal thickness and differentiated epidermal dysplasia in mice. Our data suggest that tapinarof may have different effects on varied types of psoriasis.
科研通智能强力驱动
Strongly Powered by AbleSci AI