化学
植物化学
癌症研究
细胞生物学
肝细胞癌
生物化学
下调和上调
药理学
工作(物理)
细胞培养
作者
Wenjing Xu,Yanyan Xu,Seung Hyeok Han,Yuqi Dang,Changfeng Xue,Jingqi Zhou,Siyi He,Yongfang Gong,Yan Yang
出处
期刊:Phytomedicine
[Elsevier BV]
日期:2025-12-03
卷期号:150: 157655-157655
标识
DOI:10.1016/j.phymed.2025.157655
摘要
Sal B impedes HCC by targeting MST1/2-YAP axis to drive pSmad3L/C conversion. This work identifies the first phytochemical strategy against HCC that reprograms YAP/pSmad3C-L interactions, positioning MST1/2-YAP-driven phospho-Smad3 conversion as a promising therapeutic axis.
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