液体活检
微泡
医学
癌症
抗药性
癌症研究
药理学
化学
生物
内科学
小RNA
微生物学
生物化学
基因
作者
Sidhanti Nyahatkar,Ketki Kalele
标识
DOI:10.1016/j.jlb.2024.100144
摘要
Cancer drugs and therapeutics resistance are a complicated domain of cancer treatment. Extracellular vesicles (EVs) based cancer investigation reveals several complicated concepts about cancer. EVs are associated with cellular communication. Its bioactive molecular transportation reprograms in significant ways. Exosomes an exciting EVs subpopulation work as masterminds in cancer development and progression. Studies over the past decade have elucidated that exosomes play a vital role in intercellular communication within the tumor microenvironment (TME), influencing pathways such as hypoxia-induced epithelial-mesenchymal transition (EMT), cancer stemness, angiogenesis, and metastasis. Tumor-derived exosomes (TEXs) associated with drugs and therapeutics resistance development. This article focuses on understanding exosome biology and its implications in cancer drug and therapeutics resistance, exosome-based liquid biopsy application in resistance detection, limitations, and future orientation in this domain.
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