检出限
荧光
左旋多巴
化学
铜
多巴胺
选择性
猝灭(荧光)
二羟基苯丙氨酸
组合化学
核化学
色谱法
生物化学
帕金森病
有机化学
疾病
医学
病理
内科学
物理
催化作用
量子力学
作者
Susan Varghese,N. S. N. M. S. Chandran,Anju S. Madanan,Merin K. Abraham,Ali Ibrahim Shkhair,Geneva Indongo,Greeshma Rajeevan,N. S. Vijila,B. K. Arathy,Sony George
标识
DOI:10.1002/slct.202400603
摘要
Abstract L‐3,4‐dihydroxyphenylalanine (levodopa or L–DOPA) a precursor of neurotransmitter dopamine, has been universally prescribed as a gold standard for treatment of Parkinson's Disease (PD). However, direct administration of L–DOPA has risky adverse effects which makes it challenging in the treatment of PD. Hence developing simple detection platform for sensing of L–DOPA is significant. In this work, we have developed cysteine stabilized copper nanocluster quenched with Fe 2+ (Fe 2+ @cys@CuNC) and used as both fluorescent and colorimetric probe for detection of L–DOPA. L–DOPA attributed a fluorescence quenching effect on developed probe. Fe 2+ @cys@CuNC detected L–DOPA within a linear range from 0.06 mM to 1.31 mM with a low limit of detection (LoD) of 6.57 nM. The probe also exhibited high selectivity for L–DOPA over other biomolecules and neurotransmitters. Furthermore, the capability of this probe was validated by sensing L–DOPA from human serum with excellent recovery rates of 85.75 % to 115.07 %. A low‐cost paper strip‐based portable detection platform was also developed for visual detection of L–DOPA.
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