肿胀 的
壳聚糖
共价键
原位
纤维素
低聚糖
细菌纤维素
化学工程
化学
高分子化学
化学改性
多糖
材料科学
有机化学
复合材料
工程类
作者
Chenrui Yu,Zhenxing Han,Han‐Dong Sun,Jie Tong,Ziwei Hu,Yu Wang,Fengyuan Xu,Wenjin Yue,Senhe Qian,Guangjun Nie
标识
DOI:10.1016/j.ijbiomac.2024.131280
摘要
Bacterial cellulose (BC) is an ideal candidate material for drug delivery, but the disbalance between the swelling behavior and mechanical properties limits its application. In this work, covalent crosslinking of γ-polyglutamic acid (γ-PGA) with the chitosan oligosaccharide (COS) embedded in BC was designed to remove the limitation. As a result, the dosage, time, and batch of COS addition significantly affected the mechanical properties and the yield of bacterial cellulose complex film (BCCF). The addition of 2.25 % COS at the incubation time of 0.5, 1.5, and 2 d increased the Young's modulus and the yield by 5.65 and 1.42 times, respectively, but decreased the swelling behavior to 1774 %, 46 % of that of native BC. Covalent γ-PGA transformed the dendritic structure of BCCF into a spider network, decreasing the porosity and increasing the swelling behavior by 3.46 times. The strategy balanced the swelling behavior and mechanical properties through tunning hydrogen bond, electrostatic interaction, and amido bond. The modified BCCF exhibited a desired behavior of benzalkonium chlorides transport, competent for drug delivery. Thereby, the strategy will be a competent candidate to modify BC for such potential applications as wound dressing, artificial skin, scar-inhibiting patch, and so on.
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