医学
毛霉病
泊沙康唑
曲菌病
组织病理学
焦痂
鼻窦炎
鼻子
皮肤病科
两性霉素B
外科
病理
抗真菌
免疫学
作者
Sejal M Bhavsar,Alina Sheikh,Fumiko Dekio,Asif Noor
出处
期刊:Case Reports
[BMJ]
日期:2022-12-01
卷期号:15 (12): e252265-e252265
标识
DOI:10.1136/bcr-2022-252265
摘要
An adolescent boy with newly diagnosed T-cell acute lymphoblastic leukaemia developed right eye and facial pain, and a 1 cm × 2 cm area of black eschar over his hard palate. Initial differential diagnosis included rhinocerebral mucormycosis and aspergillosis, and he was started on liposomal amphotericin B. Later, he underwent nine surgical debridements of his sinus cavities, resection of a third of his palate and right orbital exenteration. While histological specimens exhibited features of both Aspergillus and Mucor , a PCR assay detected Penicillium chrysogenum . He was successfully treated with amphotericin B and Posaconazole. P. chrysogenum has been reported in a rare case of endocarditis, a case of post-traumatic endophthalmitis, disseminated infection in a child with Henoch-Schonlein syndrome, and one fatal adult case of invasive rhinosinusitis. While infection from Penicillium species is rare, it should be considered as a cause of invasive rhinosinusitis in cases of unclear histopathology.
科研通智能强力驱动
Strongly Powered by AbleSci AI