壳聚糖
纳米复合材料
剥脱关节
抗菌活性
热重分析
热稳定性
核化学
傅里叶变换红外光谱
化学
纳米技术
材料科学
化学工程
细菌
石墨烯
生物
工程类
遗传学
作者
K. Kasirajan,Balaji Murugesan,Nithya Pandian,Shanmugam Muthusubramanian,Balamurugan Selvaraj,M. Karunakaran
标识
DOI:10.1016/j.ijbiomac.2020.02.003
摘要
A bacterial and viral infection causes life threatening diseases owing to the abuse of antibiotics and the development of antibiotic resistance microbes. Currently, biopolymers have been considered as the most promising materials in the medical field. Herein, the biogenic chitosan-functionalized MoS2 nanocomposite was prepared by the hydrothermal method with the liquid exfoliation process. The X-ray diffraction (XRD) results of chitosan–MoS2 hybrid nanocomposite revealed that MoS2 nanoparticle was found to be 42 nm with a hexagonal crystal structure. FTIR and Raman spectrum revealed that the nitrogen functionalities in the chitosan interacted with MoS2 to form the nanocomposite. The XPS spectrum of chitosan–MoS2 nanocomposite confirms that C, N, O, Mo, and S exist in the nanocomposite. Thermal gravimetric analysis (TGA) and Differential thermal analysis (DTA) analysis showed that the chitosan–MoS2 nanocomposite has higher thermal stability up to 600 °C. In the antibacterial application the chitosan–MoS2 hybrid nanocomposite shows zones of inhibition against S. aureus as 22, 28, and 32 mm, and against E. coli as 26, 30, and 35 mm. In the anticancer analysis, chitosan–MoS2 hybrid nanocomposites showed a maximum cell inhibition of 65.45% at 100 μg/mL−1, resulting in the most significant MCF-7 cell inhibition.
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