Are deep eutectic solvents useful in chromatography? A short review

A literature update has been done concerning Deep Eutectic Solvents (DES) use in chromatography applications. The literature survey was based on the period from 2010 till 2020 and manuscripts reported in the data bases Web of Science and Scopus. The use of DES as mobile phase and mobile phase additives, stationary phases and solid phase modifiers and the use of DES as reaction solvents for chromatography use, were evaluated. Emphasis was placed on the differentiation of DES and Ionic Liquids (ILs) and the advanced green characteristics of the new solvents as compared with traditional organic solvents and ILs with a look into the drawbacks and future perspectives in the field of separation methods.