Electrochemical Synthesis of 2-Oxa-bicyclo[2.1.1]hexanes by Anodic Oxidation-Cyclization Relay Strategy

A general electrosynthetic strategy for the preparation and direct functionalization of 2-oxa-bicyclo[2.1.1]hexanes (i.e. 2-oxa-BCHs) from hydroxymethyl-substituted bicyclo[1.1.0]butanes is reported. The method relies on the anodic generation of electrophilic heteroatom-centred species,...